Grottke oliver

Grottke oliver

Joanne van Ryn 1 , Oliver Grottke 2 , Henri Spronk 3 Affiliations 1 Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Street 65, Biberach 88397, Germany. Jul 1, 2019 · Oliver Grottke. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine201826 Nov 29, 2018 · Background Andexanet alfa (AnXa; Andexxa) was developed as a specific antidote for direct and indirect factor Xa (FXa) inhibitors. Grottke is highly rated in 3 conditions, according to our data. 05 versus PS and PR. Dec 8, 2022 · Jürgen Leick 1 , Oliver Grottke 2 , Mehmet Oezkur 3 , Norman Mangner 4 , Tommaso Sanna 5 , Fadi Al Rashid 6 , Christophe Vandenbriele 7 8 Affiliations 1 Heartcenter Trier, Krankenhaus der Barmherzigen Brüder Trier, Nordallee 1, 54296 Trier, Germany. Conley, 3 and Markus Honickel 1 Oliver Grottke 1 Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany Purpose of review: Direct oral anticoagulants (DOACs) are increasingly prescribed for prevention of thromboembolic events. 25 h-index 146 Publications 1st-year-citations. Revised 28 December, 2016. Thus, trauma care providers are facing a steadily raising number of injured patients on DOACs. Nov 7, 2021 · Idarucizumab may be considered the optimal treatment for emergency reversal of dabigatran anticoagulation. (Reproduced with permission from Collins PW, Cannings-John R By Oliver Grottke, Oliver Prexl, Martin Bruckbauer, Wolfgang Voelckel | Biomed Central. Jamieson, Jerrold H. }, author={Farahnaz Rayatdoost and Katharina Deventer and Rolf Rossaint and Herbert Sch{\"o}chl and Oliver Grottke}, journal={British journal of anaesthesia}, year={2023 Jan 18, 2024 · Robert Louis Grottke, 93, recently passed away. Herbert Schoechl Jul 14, 2017 · Grottke, 2015 : Pig: Blunt liver injury: 30 mg/kg bid, 3 days, oral, then i. * P < 0. Dec 11, 2020 · Julia K. Affiliation 1 From the Departement of Anesthesiology and Intensive Care Medicine, University Hospital of Salzburg (BZ), Departement of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg (WV, HS), Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Centre Thomas Knott, Sebastian Ullrich, Oliver Grottke, Thomas-Peter Fries, Marcus Gerressen, Thomas Martin Deserno, Rolf Rossaint, Torsten W. 5–7 The risk of intracranial hemorrhages was lower with all the DOACs compared with warfarin, 8 although the rate Aug 6, 2021 · Specific antagonists have been developed for the reversal of direct oral anticoagulants (DOAC). H. 5, 75, 150, and 300 ng ml −1) using a panel of coagulation parameters, including conventional coagulation assays, thrombin generation, and a newly developed viscoelastometric device. Download now! May 1, 2024 · In the clinical scenarios of DOAC intake before urgent procedures and DOAC-induced bleeding, practitioners should evaluate the risk of bleeding of the procedure and the severity of the DOAC-induced bleeding before initiating treatment. Published online: 2019-10-01 38 Fibrinogen Supplementation and Its Indications Oliver Grottke, MD, PhD1 Shuba Mallaiah, MD2 Keyvan Karkouti, MD3 Fuat Saner, MD4 Thorsten Haas, MD5 1 Department of Anesthesiology, RWTH Aachen University Hospital, Address for correspondence Oliver Grottke, MD, PhD, Department of Aachen, Germany Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 2 Apr 14, 2010 · Oliver Grottke, 1, 2 Till Braunschweig, 3 Dietrich Henzler, 4 Mark Coburn, 1 Rene Tolba, 2 and Rolf Rossaint 1 Oliver Grottke 1 Department of Anaesthesiology, RWTH Aachen University Hospital Pauwelsstrasse 30, D-52074 Aachen, Germany Sep 9, 2016 · Oliver Grottke has received research funding from Boehringer Ingelheim GmbH & Co KG, Novo Nordisk, Biotest, CSL Behring, and Nycomed; and honoraria for lectures and consultancy support from Baxalta, Bayer HealthCare, Boehringer Ingelheim GmbH & Co, CSL Behring, Octapharma, Sanofi, Pfizer, and Portola Pharmaceuticals Inc. In order to honor his memory, donations can be made to Lambs Farm, Liberty Oliver Grottke 1 , Peter Johannes Dietrich, Stefanie Wiegels, Frank Wappler Affiliation 1 *Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany; and †Department of Anesthesiology, University Witten/Herdecke, Cologne, Germany. 1055/s-0039-1696946 Corpus ID: 203639791; Fibrinogen Supplementation and Its Indications @article{Grottke2019FibrinogenSA, title={Fibrinogen Supplementation and Its Indications}, author={Oliver Grottke and Shuba Mallaiah and Keyvan Karkouti and Fuat Hakan Saner and Thorsten Haas}, journal={Seminars in Thrombosis and Hemostasis}, year={2019}, volume={46}, pages={038 - 049}, url={https Oct 21, 2015 · Oliver Grottke, Sam Schulman, Four-factor Prothrombin Complex Concentrate for the Management of Patients Receiving Direct Oral Activated Factor X Inhibitors, Anesthesiology, 10. 1186/cc13717, 18, 1, (R27), (2014). nonspecific hemostatic agents in the perioperative setting are needed to evaluate the effectiveness and safety of the hemostatic agents. Results: Patients Oct 1, 2019 · DOI: 10. Franz Rehrl Platz 5, 5020 Affiliation 1 Oliver Grottke, MD PhD, Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany, Tel. Crit Care 2014; 18:R27. METHODS This study comprised three parts. Jun 13, 2019 · Oliver Grottke, 1, ∗ Till Braunschweig, 2 Rolf Rossaint, 1 Necib Akman, 1 Janet M. 2019; 131 (5):1153–65. Apr 28, 2016 · Grottke O, Braunschweig T, Spronk HM, Esch S, Rieg AD, van Oerle R, et al. v. 0000000000002910, (1), (2019). Rieg, Rene van Oerle, Hugo ten Cate, Christina Fitzner, Rene Tolba, Rolf Rossaint; Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. RWTH Aachen University. Leeds, 3 Pamela B. Spronk, Stephanie Esch, Annette D. Lower anti-FXa levels (<50 ng/mL) with andexanet 500-mg bolus ± infusion were correlated with 60% less blood loss and 100% survival versus controls. Purpose of review: Trauma-induced coagulopathy is a frequent complication in severely injured patients. : +49 241 8080972 May 17, 2013 · Oliver Grottke, 1 Rolf Rossaint, 1 Yvonne Henskens, 2 Rene van Oerle, 3 Hugo ten Cate, 3 and Henri M. Donat R. ” Anesthesiology, vol. 2011; 118:1943–51. Four-factor PCC (50 or 100 U/kg) is effective in reducing blood loss in dabigatran-anticoagulated pigs, but higher doses may induce a procoagulant state. 1097/MAT. Each monthly issue features peer-reviewed articles reporting on the latest advances in drugs, preoperative preparation, patient monitoring, pain management, pathophysiology, and many other timely topics. Prospective randomized trials comparing specific vs. 0000000000001329 Corpus ID: 52910028; Impact of Direct Oral Anticoagulants in Patients With Hip Fractures @article{Bruckbauer2019ImpactOD, title={Impact of Direct Oral Anticoagulants in Patients With Hip Fractures}, author={Martin Bruckbauer and Oliver Prexl and Wolfgang G. Published content on this site is for information purposes and is not a substitute for professional Mar 27, 2018 · Oliver Prexl, # 1, 2 Martin Bruckbauer, # 1, 2 Wolfgang Voelckel, 1 Oliver Grottke, 3 Martin Ponschab, 4 Marc Maegele, 5 and Herbert Schöchl 1, 6 Oliver Prexl 1 Department of Anaesthesiology and Intensive Care Medicine AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Dr. First, in a retrospective clinical study of 264 major trauma Mar 1, 2017 · Christian Bleilevens 1 , Oliver Grottke 1 , Sabine Groening 1 , Markus Honickel 1 , Rüdger Kopp 2 , Smriti Singh 3 , Jutta Arens 4 , Rolf Rossaint 1 Affiliations 1 Department of Anesthesiology, University Hospital RWTH Aachen University, Aachen, Germany. 122, no. Sep 1, 2016 · Schöchl, Herbert, Grottke, Oliver and Maegele, Marc. The reversal potential of andexanet alfa, various 4F-PCCs, and activated PCC was investigated ex vivo in human blood anticoagulated with rivaroxaban (37. Voelckel and Bernhard Ziegler and Oliver Grottke and Marc Maegele and Herbert Sch{\"o}chl}, journal Mar 5, 2020 · Jutta Arens and Oliver Grottke contributed equally to this work. Data are mean ± sd. 7%) without any antithrombotic therapy (no-ATT), 59 (18. Associate Professor Oliver Grottke RWTH Aachen University, Aachen (Germany) Contributor content ESC 365 is supported by. First, in a retrospective clinical study of 264 major trauma patients, the clotting time (CT) in Herbert Schöchl 1 , Oliver Grottke, Christoph J Schlimp Affiliation 1 1Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Vienna, Austria 2AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University Salzburg, Salzburg, Austria. 1182/blood-2011-03-343046. Grottke, Oliver License Information. Matthias Grottke; Francisco Espín; Oliver Beck; By 2006 the common expectation was that crystalline PV modules produced in Europe by a leading manufacturer (and certified according to IEC 61215 Jun 18, 2019 · 19. Ziel ist auch 2011 wieder die Darstellung aktueller Forschungsergebnisse und die Vertiefung der Gespräche zwischen Wissenschaftlern, Industrie und Anwendern. 0000000000001139 Corpus ID: 212565481; Toward a Long-Term Artificial Lung @article{Arens2020TowardAL, title={Toward a Long-Term Artificial Lung}, author={Jutta Arens and Oliver Grottke and Axel Haverich and Lars S. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Intraoperative wake-up test. 4%) on COU, and 54 (16. Methods In this retrospective study, we investigated all TBI patients ≥60-years-old who Home | Indian Affairs Feb 25, 2020 · DOI: 10. Markus Honickel, Till Braunschweig, Rolf Rossaint, Christian Stoppe, Hugo ten Cate, Oliver Grottke; Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma. Grottke O, van Ryn J, Spronk HM, Rossaint R. In worldwide health systems, regional anaesthesia (RA) is not applied as frequent as it should be and benefits to patient's cure and cost savings are wasted. Research Fields. Conley, Rolf Rossaint; Reversal of Apixaban Anticoagulation with Reduced Doses of Andexanet Alfa in a Oliver Grottke 1 , Dietmar Fries, Bartolomeu Nascimento Affiliation 1 aDepartment of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany bDepartment of Surgical and General Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria cDepartment of Surgery, Sunnybrook Health Sciences Centre, University of Toronto Randomized clinical trial data demonstrate that activated factor X inhibitor therapies are noninferior to other anticoagulants such as vitamin K antagonists. Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria. They performed literature search and prepared the manuscript. All rights reserved. Oliver Grottke, MScPH Koordination Hämostaseologie / Konsildienst / Patient Blood Management Weiterbildungsermächtigung für die Hämostaseologie gemeinsam mit der Med. Mar 11, 2015 · Grottke O, van Ryn J, Spronk HM, Rossaint R. J Am Coll Cardiol. 9 (2016): e275-e276. Pollack, Alex C. Establishment of venous access can be challenging, and the intraosseous (IO) route is a Mar 1, 2022 · The possible anticoagulant effect of this "autoheparinization" has been suggested as a potential driver of trauma-induced coagulopathy. Recent findings: Despite a predictable pharmacokinetic profile, the resulting plasma levels of trauma patients upon admission No other journal can match Anesthesia & Analgesia for its original and significant contributions to the anesthesiology field. Maier, Rolf Rossaint, Thomas Schmitz-Rode, Hans Peter Wendel, and Ulrich Steinseifer prepared and reviewed the manuscript. Conley 3, Markus Honickel 1 Show more Add to Mendeley Mar 27, 2018 · Oliver Prexl, # 1, 2 Martin Bruckbauer, # 1, 2 Wolfgang Voelckel, 1 Oliver Grottke, 3 Martin Ponschab, 4 Marc Maegele, 5 and Herbert Schöchl 1, 6 Oliver Prexl 1 Department of Anaesthesiology and Intensive Care Medicine AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Dr. -Doz. Grottke, Oliver, and Jerrold H. Aug 1, 2019 · Author links open overlay panel Oliver Grottke 1, Till Braunschweig 2, Rolf Rossaint 1, Necib Akman 1, Janet M. Current guidelines recommend specific antidots and PCCs in DOAC-related major bleeding. Each model is unique and should be chosen based on how well it aligns with the specific scientific objectives of the study. Huisman, Dara G. doi: 10. Aug 23, 2023 · In a porcine polytrauma model with major bleeding on apixaban, andexanet dose dependently decreased anti-FXa activity. 1097/ALN. To correct coagulopathy and restore haemostasis, these patients have traditionally been treated with fresh frozen plasma, but in the last decade, there has been a shift from empirical therapy to targeted therapy with coagulation factor concentrates and other haemostatic agents. 5 Fibrinogen concentrate therapy in postpartum hemorrhage: effects on blood loss and transfusion of allogeneic blood products within 24 hours of study treatment in patients with FIBTEM A5 levels or < 12 mm, and plasma fibrinogen levels above or below 2 g/L. Correspondence to Oliver Grottke, MD, PhD, MScPH, Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany. Klinik IV Stellvertretender Transfusionsbeauftragter Facharzt für Anästhesiologie ZB Notfallmedizin ZB Hämostaseologie Publikationsliste ogrottke Aug 10, 2023 · The preoperative coagulation management strategy for the planned surgical intervention was based on the administration of rFVIIIFc on demand. Levy. Accepted 13 February, 2017 Jun 1, 2019 · Oliver Grottke Background: Idarucizumab is licensed to reverse dabigatran in life-threatening haemorrhage. 3University Hospital of the RWTH Aachen Grottke, Oliver ; Afshari, Arash; Ahmed, Aamer et al. Germany. His top areas of expertise are Blood Clots, Disseminated Intravascular Coagulation, COVID-19, and Factor 10 Deficiency. Jun 22, 2015 · The Regional Anaesthesia Simulator and Assistant project combines image processing, physiological models, and virtual reality to support ultrasound-guided and electrical nerve stimulation-guided RA. 1097/bot. "Comparing the viscoelastomeric fibrin polymerization assays FIBTEM ® (ROTEM) vs. Comparing the viscoelastomeric fibrin polymerization assays FIBTEM ® (ROTEM) vs. infusion to reach 1,161 ± 372 ng/mL in plasma: Idarucizumab 30 mg/kg, 60 mg/kg, and 120 mg/kg Dose-dependent reduction of total blood loss Dose-dependent reduction in aPTT 100% survival in 60 mg/kg, and 120 mg/kg groups Dose-dependent increase in ETP (CAT) Mar 27, 2018 · Oliver Prexl 1 2 , Martin Bruckbauer 1 2 , Wolfgang Voelckel 1 , Oliver Grottke 3 , Martin Ponschab 4 , Marc Maegele 5 , Herbert Schöchl 6 7 Affiliations 1 Department of Anaesthesiology and Intensive Care Medicine AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Dr. Main Outcome Measurements: Time to surgery, blood loss, mortality, hospital length of stay, red blood cell transfusion, use of reversal agents, and Charlson Comorbidity Index. de Feb 1, 2024 · Methods. Anesthesiology. Functional Fibrinogen ® (TEG): or why is a higher threshold for fibrinogen substitution better than a lower one? Clin Chem Lab Med 2016; 54:e275–e276. Times (min) to the onset of breathing, first reaction, elevation of the head, and the motion of the legs in group PS (propofol and sufentanil), group PR (propofol and remifentanil), and group DR (desflurane and remifentanil). Tel: +49 241 8080972; e-mail: [email protected] Supplemental digital content is available for this article. Axel Haverich, Lars S. 1097/BOT. ). During liver transplantation higher levels were recommended. Oliver Grottke 1 , Jerrold H Levy Affiliation 1 From the Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany (O. Text and Data Mining valid from 2024-05-10 Version of Record valid from 2024-05-10 Mar 27, 2018 · Background Traumatic brain injury (TBI) is the leading cause of death among trauma patients. ); and Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina (J. Functional Fibrinogen ® (TEG): or why is a higher threshold for fibrinogen substitution better than a lower one?" Clinical Chemistry and Laboratory Medicine (CCLM) 54, no. Leeds 3, Pamela B. E-mail: [email protected] Received 7 December, 2016. Join Facebook to connect with Oliver Grottke and others you may know. Spronk 3 , * Oliver Grottke 1 Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany Nov 29, 2018 · Oliver Grottke, Necib Akman, Till Braunschweig, Pamela B. med. Dr. He attended school at Northwestern University. Patients under antithrombotic therapy (ATT) carry an increased risk for intracranial haematoma (ICH) formation. Coagulation View papers (52) Dabigatran View papers (43) Jul 20, 2012 · Oliver Grottke, Joanne van Ryn, Henri MH Spronk, Rolf Rossaint, Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model, Critical Care, 10. Optimal reversal strategy remains to be determined in future tri … Oliver Grottke via Europe PubMed Central Correction to: Sub-anesthetic Xenon Increases Erythropoietin Levels in Humans: A Randomized Controlled Trial. L. Maier and Thomas Schmitz-Rode and Ulrich Steinseifer and Hans Peter Wendel and Rolf Rossaint}, journal={Asaio Journal}, year={2020}, volume={66}, pages={847 - 854 Aug 27, 2020 · Grottke O, Schulman S. Fig. Jan 1, 2019 · DOI: 10. Oliver Grottke ist FA fur Anästhesiologie im Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074 Aachen. Böhm, 1 Helge Güting, 1 Sophie Thorn, 2 Nadine Schäfer, 1 Victoria Rambach, 1 Herbert Schöchl, 4, 5 Oliver Grottke, 6 Rolf Rossaint, 6 Simon Stanworth, 7 Nicola Curry, 7 Rolf Lefering, 1 Marc Maegele, 1, 3 and CENTER-TBI Participants and Investigators Oliver Grottke 1 , Dietrich Henzler, Rolf Rossaint Affiliation 1 Department of Anaesthesiology, Institute for Laboratory Animal Science, RWTH Aachen University Hospital, Pauwelsstrasse 30, D-52074 Aachen, Germany. / Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation. G. Oliver Grottke. Spahn. Idarucizumab, a specific dabigatran reversal agent, reduces blood loss in a porcine model of trauma with dabigatran anticoagulation. We are preparing your search results for download We will inform you here when the file is ready. Kuhlen: Medical training simulators for bilateral sagittal split osteotomy and regional aneasthesia in virtual environments. Δ P < 0. Spyropoulos Copyright® 2024 Radcliffe Medical Media. Oct 23, 2013 · Markus Honickel, Benjamin Maron, Joanne van Ryn, Till Braunschweig, Hugo ten Cate, Henri M. Dec 7, 2016 · Address reprint requests to Oliver Grottke, MD, PhD, Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany. Four‐factor prothrombin complex concentrate for the management of patients receiving direct oral activated factor X inhibitors. ) Ihre E-Mail-Adresse wird nicht veröffentlicht, aber der von Ihnen angegebene Name wird für die Nutzer sichtbar sein. Schöchl H, Grottke O, Maegele M. Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. 05 versus PS. Spronk, Hugo ten Cate, Joanne van Ryn, Rolf Rossaint; Prothrombin Complex Concentrate in Combination with Fibrinogen Plus Tranexamic Acid Is More Effective Than Mono-Therapy with Prothrombin Complex Concentrate in a Dabigatran Anticoagulation Experimental Polytrauma Model. 2015, pp Oliver Grottke Thomas Martin Deserno Segmentation of multiple muscles in magnetic resonance imaging (MRI) is challenging because of the similar intensities of the tissue. 1,2 PCCs contain either three or four coagulation factors (factors II, IX, and X, with or without factor VII) and, depending on formulation, low doses of coagulation inhibitors such as protein C, protein S, and heparin (). ogrottke@ukaachen. [Google Scholar] OA Prof. Mar 1, 2023 · @article{Rossaint2023TheEG, title={The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition}, author={Rolf Rossaint and Arash Afshari and Bertil Bouillon and Vladim{\'i}r {\vC}ern{\'y} and Diana Cimpoesu and Nicola S Curry and Jacques Duranteau and Daniela Carmen Filipescu and Oliver Grottke and Aug 18, 2011 · Oliver Grottke, Till Braunschweig, Henri M. H. / Clinical guideline on reversal of direct oral anticoagulants in patients with life threatening bleeding. The possible anticoagulant effect of this “autoheparinization” has been suggested as a potential driver of trauma-induced coagulopathy. Institute of Anesthesiology, University and University Hospital of Zurich, Zurich, Switzerland. [Google Scholar] . (Anesthesiology 2017; 127:852-61). Sports medicine (Auckland, N. Sep 29, 2015 · Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation Oliver Grottke is on Facebook. May 2, 2022 · Oliver Grottke has received research funding from Alveron, Bayer Healthcare, Boehringer Ingelheim, Biotest, CSL Behring, Octapharma, Novo Nordisk, Nycomed and Portola. We investigated the impact of these reversal agents on the plasma concentration and visco-elastic test results of dabigatran and factor Xa inhibitors. However, this study suggests that PCC may be similarly effective as idarucizumab and could therefore be valuable when idarucizumab is unavailable. The Regional Anaesthesia Simulator and Grottke O, Honickel M, van RJ, ten Cate H, Rossaint R, Spronk HM. 2024 ; Bind 41, Nr. Fatal hemorrhage is rarer when DOACs are given (nonvalvular atrial fibrillation: odds Sep 11, 2023 · Conclusions: Recognizing the diverse strengths and weaknesses of large animal models is critical for trauma and hemorrhage research. 2015;66(13):1518–1519. Grottke, Oliver，现任职于Rheinisch-Westfälische Technische Hochschule Aachen，曾任职于帕拉塞尔萨斯私立医科大学、汉堡大学等机构，个人H指数为24，累计发表论文150篇，论文总被引数累计2037次，主要研究方向涵盖医学、工程学、生物化学,遗传学和分子生物学、化学工程等领域，在European Heart Journal、The Lancet Jan 1, 2019 · Grottke O, 0000-0002-0722-3122, RWTH Aachen University Journal of Orthopaedic Trauma , 01 Jan 2019 , 33(1): e8-e13 DOI: 10. Conley, Rolf Rossaint; Comparison of Second and First Generation of Andexanet Alfa in a Porcine Polytrauma Model with Apixaban Anticoagulation. He has also received honoraria for lectures and consultancy support from Bayer Healthcare, Boehringer Ingelheim, CSL Behring, Octapharma, Sanofi, Shire, Pfizer and Portola. 0000000000001329 PMID: 30277979 Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model Oliver Grottke1*, Joanne van Ryn2, Henri MH Spronk3 and Rolf Rossaint1 Sep 5, 2016 · Background: Direct (non-vitamin-K-dependent) oral anticoagulants (DOAC) are given as an alternative to vitamin K antagonists (VKA) to prevent stroke and embolic disease in patients with atrial fibrillation that is not due to pathology of the heart valves. 4, Apr. Blood. Levy, Charles V. Franz Rehrl Platz 5, 5020 Three-hundred twenty patients 65 years of age or older with isolated HF were enrolled into the study: 207 (64. Vollstandiges Profil, Bewertungen des Patienten, Telefonnummer, E-Mail und Adresse. FAQ Prothrombin complex concentrates (PCCs) are recommended in preference to other treatments such as therapeutic plasma for urgent reversal of vitamin K antagonists. It has been approve… Nov 1, 2023 · @article{Rayatdoost2023ComparativeAO, title={Comparative analysis of andexanet alfa and prothrombin complex concentrate in reversing anticoagulation by rivaroxaban ex vivo. Dec 6, 2014 · Oliver Grottke, Markus Honickel, Henri M. By strategically considering each model's advantages and limitations, we can enhance our 44 Grottke et al. He worked for Arthur Andersen. 1160/th15-03-0266, 115, 02, (271-284 Oliver Grottke *, James Aisenberg, Richard Bernstein, Patrick Goldstein, Menno V. Sep 3, 2015 · Europe PMC is an archive of life sciences journal literature. Z. Franz Rehrl Platz 5, 5020 59 . Grottke, Oliver ; Honickel, Markus ; van Ryn, Joanne et al. We investigated whether thromboelastometry can be used to detect trauma-induced autoheparinization. The World Federation of Hemophilia recommends FVIII levels of at least 80–100% presurgery and of 60–80% for days 1–3 postsurgery [ 5 ]. he bloodstream. His clinical research consists of co-authoring 121 peer reviewed articles in the past 15 years. Nov 29, 2018 · Oliver Grottke, Necib Akman, Till Braunschweig, Pamela B. Spronk, Rolf Rossaint, Oliver Grottke, Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model, Thrombosis and Haemostasis, 10. Methods: This study comprised three parts. Facebook gives people the power to share and makes the world more open and connected. After Mar 1, 2023 · Rolf Rossaint 1 , Arash Afshari 2 , Bertil Bouillon 3 , Vladimir Cerny 4 5 , Diana Cimpoesu 6 , Nicola Curry 7 8 , Jacques Duranteau 9 , Daniela Filipescu 10 , Oliver Grottke 11 , Lars Grønlykke 12 , Anatole Harrois 9 , Beverley J Hunt 13 , Alexander Kaserer 14 , Radko Komadina 15 , Mikkel Herold Madsen 2 , Marc Maegele 16 , Lidia Mora 17 Mar 13, 2018 · Oliver Grottke has received research funding from Boehringer Ingelheim GmbH & Co KG, Novo Nordisk, Biotest, CSL Behring, and Nycomed; and honoraria for lectures and consultancy support from Baxalta, Bayer HealthCare, Boehringer Ingelheim GmbH & Co, CSL Behring, Octapharma, Sanofi, Pfizer, and Portola Pharmaceuticals Inc. Oliver Grottke practices in Aachen, Germany. OA Priv. I: European Journal of Anaesthesiology . 9%) on DOACs. There is a paucity of data about the role of direct oral anticoagulants (DOACs) among TBI patients. “Prothrombin complex concentrates in trauma and perioperative bleeding. In den letzten Jahren hat sich der Workshop "Bildverarbeitung für die Medizin" durch erfolgreiche Veranstaltungen etabliert. 4 DOACs also have favorable safety and efficacy profiles, as demonstrated by evidence from ‘‘real-world’’ cohorts. gx in sn nl ei cx xd uu ar hk